Trending Federal Contract Opportunities: September 18, 2026

These are the ten active federal contract opportunities the G2X community researched most over the last 24 hours. Army CASTLE KEEP development, ARPA-H tissue-aging research, and VA billing code sets lead a list spanning market research, draft requirements, and open solicitations.

1. Army CASTLE KEEP cloud development

Army Contracting Command–Aberdeen Proving Ground is gathering industry input on developing and sustaining CASTLE KEEP for Headquarters, Department of the Army G-2. The portal supports automated workflows, reporting, metrics, analysis, and information sharing for the Army’s sensitive compartmented information security community.

The work would operate in an Army commercial-cloud environment and support Special Security Officers and Representatives. The Army is assessing software-development and sustainment capabilities through an RFI, rather than requesting priced proposals. Responses to solicitation W56KGY26CKRFI0001 are due September 22 at noon Eastern.

Sources

Official opportunity notice — SAM.gov.

Detailed opportunity overview — G2X.

SAM.gov — SAM.gov.

2. ARPA-H COSMOS tissue-aging research

The Advanced Research Projects Agency for Health is seeking research on whether microgravity in low Earth orbit accelerates aging in human tissue. Its COSMOS initiative pairs Earth-based and orbital experiments using microphysiological systems and organoids representing brain, cardiac, uterine, or kidney tissue.

Each team would focus on one organ, combining biological models, engineering, and computational analysis. If accelerated aging can be demonstrated at a useful rate, the program aims to develop a microgravity-based drug-screening platform. ARPA-H anticipates multiple Other Transaction awards under solicitation ARPA-H-SOL-26-165. The official response date is October 7 at 2 p.m. Eastern.

Sources

Official opportunity notice — SAM.gov.

Detailed opportunity overview — G2X.

ARPA-H-SOL-26-165_COSMOS_ISO.docx — SAM.gov.

SAM.gov — SAM.gov.

3. VA Community Care billing code sets

The Department of Veterans Affairs’ Enterprise Procurement Office is assessing capabilities to develop and maintain billing code sets aligned with Community Care Referral Guidelines. The requirement covers reviewing existing codes, identifying gaps and obsolete material, validating changes, and delivering files that support claims adjudication.

The work centers on maintained data deliverables and coding expertise, including version control and regular releases, rather than procuring a hosted application. The Strategic Acquisition Center in Fredericksburg is the listed contracting office. This is market research under solicitation 36C10G26Q0088; the updated response deadline is September 29 at 3 p.m. Eastern.

Sources

SAM.gov — SAM.gov.

Detailed opportunity overview — G2X.

Attachment 1 Draft Performance Work Statement Code Sets.pdf — SAM.gov.

Attachment 2 RFI 2 Questions.pdf — SAM.gov.

4. VA Compensation and Pension help desk

The VA Technology Acquisition Center in New Jersey is gathering capability information for Tier 2 help desk and software-deployment support for the Compensation and Pension Product Line. The requirement follows the PACT Act deployment and help desk effort and is identified as version 2.0.

VA is asking firms to map their capabilities to its draft performance work statement and assess whether it describes the support needs adequately. Responses are limited to 12 pages, with generic marketing materials excluded from review. Sources Sought solicitation 36C10B26Q0725 is an acquisition-planning step, with responses due October 1 at 10 a.m. Eastern.

Sources

SAM.gov — SAM.gov.

Detailed opportunity overview — G2X.

36C10B26Q0725.docx — SAM.gov.

RFI_SAM.gov_CP 2.0_final.pdf — SAM.gov.

5. NHLBI executive management and advisory support

The National Heart, Lung, and Blood Institute is seeking executive-management and advisory support for the Immediate Office of the Director. The work would help the institute put a new organizational structure into practice by clarifying responsibilities, workflows, decision rights, and operating procedures.

The scope also includes staff transition and change-management support, linking organizational design to daily execution. NIH’s Office of Logistics and Acquisition Operations is gathering capability information through Sources Sought solicitation 75N98026Q01237. Responses are due September 28 at 3 p.m. Eastern.

Sources

SAM.gov — SAM.gov.

Detailed opportunity overview — G2X.

RFI for IOD Executive Support.pdf — SAM.gov.

6. CDC NIOSH systematic information review

The National Institute for Occupational Safety and Health needs a contractor-operated service for systematic scientific-literature review and validation. The CDC requirement combines automated retrieval, screening, evidence extraction, and synthesis with human review, producing traceable findings that NIOSH can evaluate and reproduce.

The 36-month effort uses an existing commercial service rather than commissioning a new government-owned software platform. Work includes validation against NIOSH-generated results, additional topic evaluations, and refinement of the service as methods change. CDC’s Office of Acquisition Services is handling solicitation 75D301-26-Q-79261, with responses due September 18 at 4 p.m. Eastern.

Sources

SAM.gov — SAM.gov.

Detailed opportunity overview — G2X.

A19. 75D301-26-Q-79261.pdf — SAM.gov.

B3. Q&A.pdf — SAM.gov.

A19. 75D301-26-Q-79261 - Amendment 00001.pdf — SAM.gov.

7. FDA food and cosmetic product databases

The FDA’s Human Foods Program needs continued access to commercial food, cosmetic, packaging, and menu databases, together with the services that keep those resources useful to agency staff. The requirement includes licensed data, integration into a multi-tenant system, database maintenance, and technical and analytical support.

Training, reporting, and image-verifiable product information are also part of the scope. The procurement is for existing commercially or federally available resources, not development of a new database. FDA’s Office of Acquisition and Grants Services is handling solicitation FDA-SOL-75F40126Q00341; responses are due September 25 at 1 p.m. Eastern.

Sources

Official opportunity notice — SAM.gov.

Detailed opportunity overview — G2X.

RFQ_FDA-SOL-75F40126Q00341.pdf — SAM.gov.

SAM.gov — SAM.gov.

8. DHS network, cloud, and cybersecurity services

The Department of Homeland Security has released a final draft for Network, Cloud, and Cybersecurity Services 2.0, supporting the Office of the Chief Information Officer and its Network Operations and Security Center. The planned department-wide, single-award IDIQ covers network and cloud operations, cybersecurity monitoring, incident response, recovery, and related support.

DHS’s Information Technology Acquisition Center is collecting questions on the draft by September 22. The notice identifies October 1 as the planned final-solicitation date, so this stage is an opportunity to review and comment on the proposed requirement. The solicitation number is 70RTAC26R00000007.

Sources

SAM.gov — SAM.gov.

Detailed opportunity overview — G2X.

DRAFT NCCS RFP_9-16-2026.docx — SAM.gov.

DRAFT Attachment 1 NCCS SOW.pdf — SAM.gov.

Draft Attachment 3 NCCS Labor Category Descriptions.xlsx — SAM.gov.

DRAFT Attachment 2_NCCS Pricing Template 07152026 Draft (002) (003).xlsx — SAM.gov.

9. DISA Combined Federated Battle Laboratories Network

The Defense Information Systems Agency is gathering industry input on support for the Combined Federated Battle Laboratories Network. The effort connects the Air Force’s Mission Partner Capabilities Office with NATO and coalition partners for experimentation, testing, and interoperability work.

The scope spans network design, transition, operations, lifecycle management, architecture, and cybersecurity. Commercial components and built-in redundancy form part of the technical approach. DISA’s Mission Partner Environment acquisition organization is conducting the market research under Sources Sought solicitation HC104709250103, with responses due September 30 at 4 p.m. Eastern.

Sources

Official opportunity notice — SAM.gov.

Detailed opportunity overview — G2X.

encl2c_pws_CFBLNet_Sept2026.docx — SAM.gov.

Sources_Sought_CFBLNet.docx — SAM.gov.

SAM.gov — SAM.gov.

10. Commerce OIG cloud governance and compliance

The Department of Commerce Office of Inspector General is seeking a FedRAMP High software-as-a-service platform for governance, risk, and compliance. The system would support up to five FISMA High systems, organizing security evidence, control narratives, assessment reports, and plans of action and milestones.

The requirement combines compliance automation with human approval: AI-generated statements must be reviewed before use, and the platform must not submit materials autonomously. It is a software requirement rather than a labor-only risk-management engagement, with operational readiness expected within 12 weeks. Responses to solicitation GG000000-26-00063 are due September 28 at 11 a.m. Eastern.

Sources

SAM.gov — SAM.gov.

Detailed opportunity overview — G2X.

Competitive Solicitation_GG000000-26-00063_vF.pdf — SAM.gov.

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